4-ACO-DMT (4-Acetoxy-DMT)


4-AcO-DMT (or psilacetin) is a semi-synthetic tryptamine closely related to the psychedelic mushroom molecules psilocin and psilocybin. In fact, 4-AcO-DMT is widely known as “synthetic mushrooms.” Like psilocybin, it appears that the body metabolizes 4-AcO-DMT into psilocin.

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What to expect 4-Acetoxy-DMT

4-AcO-DMT experience is often compared to that of psilocybin, but with a more smooth, elated sensibility. High dose of 4-AcO-DMT is known for its colourful visionary effects, but moderate doses produce a visual experience similar to psilocybin, with objects appearing to breathe and wave. Many people who have taken 4-Acetoxy-DMT say that while it can be more intense than mushrooms, it’s also more predictable.

A 4-AcO-DMT experience can last anywhere between two and eight hours, depending on how much you take and how it’s consumed. When taken orally, the effects of 4-AcO-DMT are usually felt within the first 45 minutes, with the peak lasting two to three hours and the comedown at least an hour.

Safety and toxicity 4-ACO-DMT

Taking into account the pharmacological similarities, we can assume that 4-AcO-DMT is just as safe and non-addictive as psilocybin/psilocin. Although clinical research is lacking especially into its long-term effects and toxic overdose (if any) anecdotal reports support its presumed safety.

However, a number of 4-AcO-DMT trip reports report that very high doses can cause blackouts, vomiting, heart problems, hypertension, and seizures. No fatalities have been reported at least in the absence of other drugs.

The Use 

As a powder, 4-AcO-DMT is usually taken orally, but it can also be taken intranasal (snorted/insufflated). Either way, it’s processed more rapidly by the body than psilocybin mushrooms, typically resulting in a faster, more intense onset.

Oral 4-AcO-DMT dosage (in mg)

  • Threshold: 2.5 – 5
  • Light: 5 – 10
  • Common: 10 – 25
  • Strong: 25 – 40
  • Heavy: 40+

Intranasal 4-AcO-DMT dosage (in mg)

  • Threshold: <5
  • Light: 5 – 10
  • Common: 10 – 20
  • Strong: 20 – 30
  • Heavy: 30+

Many factors contribute to the 4-AcO-DMT experience, including dose, mindset, setting, and method of consumption. With that in mind, each individual journey will be unique to the person, time, and place, and there’s no way to predict exactly what will happen. But, 4-AcO-DMT does induce some common experiences and effects that can help you prepare for your journey.



Additional information

10g, 25g, 50g, 100g, 200g, 250g, 500g, 1000g



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