What is LSZ?
Lysergic acid 2,4-dimethylazetidide (also known as λ, Lambda, and LSZ) is a synthetic psychedelic of the lysergamide chemical class which produces effects considered quite similar to LSD, with a slightly shorter duration.
First synthesized in the 2000’s by a team led by David E. Nichols at Purdue University, LSZ gained popularity in the psychonaut community when it appeared on the market in 2012, distributed on blotter paper or in liquid solution under names such as “Diazedine” and “λ” (or “Lambda”)
LSZ is not considered to be addictive or physiologically toxic. Nevertheless, as with all psychedelics, adverse psychological reactions such as severe anxiety, paranoia and psychosis are always possible, particularly among those predisposed to mental illness. It is highly advised to use harm reduction practices if using this substance
LSZ, or d-lysergic acid 2,4-dimethylazetidide core polycyclic structure is an indole derivative, and has tryptamine and phenethylamine groups embedded within it. It is a semi-synthethic alkaloid of the lysergamide family and contains a core structure of lysergic acid with an amine functional group bound to RN of the chemical structure.
The structure contains a bicyclic hexahydroindole fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline, an amide group is bound. Additionally, the substitutions of the terminal nitrogen atom of the amide group form a 2,4-dimethylazetidide group. LSZ is additionally substituted at carbon 6 with a methyl group.
There are three possible stereoisomers around the azetidine ring with the (S,S)-(+) isomer being the most active. It is slightly more potent than LSD itself in drug discrimination tests using trained rats